Cancers of the pancreas use the sugar fructose, a very common component of Western diet, to activate a key cellular pathway which directs the cell division. It results in comparatively quicker growth of the cancer. This is the finding from a study conducted by researchers at UCLA’s Jonsson Comprehensive Cancer Center.It was known and believed till now that cancers use the simple sugar glucose to drive their growth. However, this study has shown a connection between fructose ad cancer proliferation.
“The bottom line is the modern diet contains a lot of refined sugar including fructose and it’s a hidden danger implicated in a lot of modern diseases, such as obesity, diabetes and fatty liver, “said Dr. Anthony Heaney, an associate professor of medicine and neurosurgery, a Jonsson Cancer researcher and senior author of the study. He also serves as the director of Pituitary Tumor and Neuroendocrine Program at UCLA. “In this study, we show that cancers can use fructose just as readily as glucose to fuel their growth.” The study was published in a recent issue of the peer-reviewed journal Cancer Research.
The study involved Heaney and his team taking sample of pancreatic cancers from patients, culturing them and growing the malignant cells in Petri dishes. It was followed by the team adding glucose to one set of cells and fructose to another. They used mass spectrometry to follow the carbon-labeled sugars in the cells. This helped them determine what exactly they were being used for and how.
From the study, Heaney found that the cancerous pancreatic cells could easily distinguish between glucose and fructose even though they are very similar in structure. The cells metabolized the sugars in very different ways. The study was funded by the National Institutes of Health, the Hirschberg Foundation and the Jonsson Cancer Center.


